Korean J Med.  2017 Feb;92(1):24-35. 10.3904/kjm.2017.92.1.24.

Updated Treatment of Chronic Hepatitis C

• Kim YS

• KMID: 2376940
• DOI: http://doi.org/10.3904/kjm.2017.92.1.24

Abstract

Hepatitis C virus (HCV) infection is one of the important causes of chronic liver diseases, including hepatic fibrosis, liver cirrhosis and hepatocellular carcinoma. The goals of hepatitis C treatment are to eradicate HCV and to prevent related hepatic complications, manifestations of HCV infection and death. A sustained virological response (SVR) is defined as undetectable serum HCV RNA by a sensitive assay at 12 or 24 weeks after treatment completion. The infection is cured in nearly 100% of patients who achieve an SVR. Newly introduced direct-acting antivirals act at a specific step of the viral life cycle and enable an SVR of over 90%. There are a number of unmet needs in HCV therapies that should be addressed, and are anticipated to be resolved in the near future.

Keyword

Hepatitis C, Chronic; Treatment

MeSH Terms

Antiviral Agents
Carcinoma, Hepatocellular
Fibrosis
Hepacivirus
Hepatitis C
Hepatitis C, Chronic*
Hepatitis, Chronic*
Humans
Life Cycle Stages
Liver Cirrhosis
Liver Diseases
RNA
Antiviral Agents
RNA