Korean J Endocr Surg.  2009 Sep;9(3):155-160. 10.16956/kjes.2009.9.3.155.

The Relationship between the p27 Expression of Papillary Thyroid Cancer Cells Obtained by FNA and Cervical Lymph Node Metastasis

• Lee KJ
• Lee JH
• Kim JS
• Kim TG
• Lee SC
• Kim JG
• Ahn CJ
• Kim SJ
• Lee DH

• KMID: 2375745
• DOI: http://doi.org/10.16956/kjes.2009.9.3.155

Abstract

PURPOSE
The p27 gene as a tumor suppressor gene is associated with colorectal cancer, gastric cancer and breast cancer. Some studies have shown a relationship between the underexpression of p27 and lymph node metastasis in papillary thyroid carcinoma. The aim of this study is to evaluate the relationship between a p27 expression of the papillary thyroid cancer cells obtained by fine needle aspiration (FNA) and cervical lymph node metastasis.
METHODS
This study included 60 patients with papillary thyroid cancer and who underwent total thyroidectomy or lobectomy. Central lymph node dissection was routinely done. Out of these patients, 30 patients underwent a FNA procedure during the operation. Immunohistochemical staining for p27 antibody was performed on the papillary thyroid cancer tissues and cells.
RESULTS
Cervical lymph node metastasis is correlated with the tumor size and lymphovascular invasion (P<0.001). The underexpression of p27 for the papillary thyroid cancer tissues and cells was associated with lymph node metastasis (P=0.009).
CONCLUSION
An evaluation of the p27 expression for the papillary thyroid cancer cells obtained by FNA may be useful as a predictor for lymph node metastasis before surgery.

Keyword

Papillary thyroid cancer; Fine needle aspiration; p27; Lymph node metastasis

MeSH Terms

Biopsy, Fine-Needle
Breast Neoplasms
Colorectal Neoplasms
Genes, Tumor Suppressor
Humans
Lymph Node Excision
Lymph Nodes*
Neoplasm Metastasis*
Stomach Neoplasms
Thyroid Gland*
Thyroid Neoplasms*
Thyroidectomy