Arch Craniofac Surg.
2017 Mar;18(1):9-15. 10.7181/acfs.2017.18.1.9.
Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
- Affiliations
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- 1Department of Plastic and Reconstructive Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. eqatom@yuhs.ac
- 2Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Bioengineering, College of Engineering, Hanyang University, Seoul, Korea.
- KMID: 2375215
- DOI: http://doi.org/10.7181/acfs.2017.18.1.9
Abstract
- BACKGROUND
Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model.
METHODS
Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared.
RESULTS
Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group.
CONCLUSION
Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
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