Blood Res.  2017 Mar;52(1):50-54. 10.5045/br.2017.52.1.50.

Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran

• Arabzadeh
• Alizadeh F
• Tavakoli A
• Mollaei H
• Bokharaei-Salim F
• Karimi G
• Farahmand
• Mortazavi
• Monavari S

• KMID: 2375204
• DOI: http://doi.org/10.5045/br.2017.52.1.50

Abstract

BACKGROUND
Due to the tropism of human parvovirus B19 to erythroid progenitor cells, infection in patients with an underlying hemolytic disorder such as beta-thalassemia major leads to suppression of erythrocyte formation, referred to as transient aplasia crisis (TAC), which may be life-threatening. We investigated the prevalence of parvovirus B19 among patients with beta thalassemia major attending the Zafar Adult Thalassemia Clinic in Tehran, Iran.
METHODS
This cross-sectional study was performed to determine the presence of parvovirus B19 DNA in blood samples and parvovirus B19 genotypes in plasma samples of patients with thalassemia major. The population consisted of 150 patients with beta-thalassemia major who attended the Zafar clinic in Tehran. Specimens were studied using a real-time polymerase chain reaction assay.
RESULTS
The prevalence of parvovirus B19 in our study population was 4%. Of 150 patients with thalassemia, six (4%) were positive for B19 DNA. There was no significant correlation between blood transfusion frequency and B19 DNA positivity. Finally, phylogenetic analysis of human parvovirus B19 revealed genotype I in these six patients.
CONCLUSION
In this study, acute B19 infections were detected in patients with beta thalassemia major. Screening of such high-risk groups can considerably reduce the incidence and prevalence of B19 infection; thus, screening is required for epidemiologic surveillance and disease-prevention measures.

Keyword

Parvovirus B19; Genotype; Thalassemia; Iranian patients

MeSH Terms

Adult
beta-Thalassemia*
Blood Transfusion
Cross-Sectional Studies
DNA
Epidemiological Monitoring
Erythrocytes
Erythroid Precursor Cells
Genotype
Humans*
Incidence
Iran*
Mass Screening
Parvovirus
Parvovirus B19, Human*
Plasma
Prevalence
Real-Time Polymerase Chain Reaction
Thalassemia
Tropism
DNA

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