Infect Chemother.  2017 Mar;49(1):1-9. 10.3947/ic.2017.49.1.1.

Molecular Epidemiology of Human Immunodeficiency Virus

• Chin BS

• KMID: 2375093
• DOI: http://doi.org/10.3947/ic.2017.49.1.1

Abstract

During the evolution of human immunodeficiency virus (HIV), transmissions between humans and primates resulted in multiple HIV lineages in humans. This evolution has been rapid, giving rise to a complex classification and allowing for worldwide spread and intermixing of subtypes, which has consequently led to dozens of circulating recombinant forms. In the Republic of Korea, 12,522 cases of HIV infection have been reported between 1985, when AIDS was first identified, and 2015. This review focuses on the evolution of HIV infection worldwide and the molecular epidemiologic characteristics of HIV in Korea.

Keyword

Human immunodeficiency virus; Molecular epidemiology; Phylogeny

MeSH Terms

Classification
HIV Infections
HIV*
Humans*
Korea
Molecular Epidemiology*
Phylogeny
Primates
Republic of Korea

Figure

• 

  Figure 1 Comparison of network analysis (A) and phylogenic tree (B). While the level of interconnection in the cluster is indistinguishable in the phylogenetic tree, network analysis reveals the level of connections. In cluster 4 (red circle), every node is connected with the other nodes while only one node is interconnected with the other two nodes in cluster 16 (blue circle) [74].

• 

  Figure 2 Neighbor-joining phylogenetic relationship generated from 2907 HIV-1 subtype B gp120 env sequences. Korean clade B (in red) formed a distinct cluster from worldwide HIV-1 subtype B sequences [66].

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