Yonsei Med J.  2016 Sep;57(5):1159-1164. 10.3349/ymj.2016.57.5.1159.

Association between Vitamin D Deficiency and Anemia in Patients with End-Stage Renal Disease: A Cross-Sectional Study

• Kim YL
• Kim H
• Kwon YE
• Ryu DR
• Lee MJ
• Park KS
• Ryu HJ
• Park JT
• Oh HJ
• Han SH
• Yoo TH
• Kang SW

• KMID: 2374161
• DOI: http://doi.org/10.3349/ymj.2016.57.5.1159

Abstract

PURPOSE
Despite new treatment strategies, anemia remains the most prevalent complication in patients with end-stage renal disease (ESRD). We investigated whether 25-hydroxyvitamin D [25(OH)D3] deficiency was associated with anemia in ESRD patients.
MATERIALS AND METHODS
We reviewed the medical records of 410 ESRD patients who had undergone renal transplantation (RTx) at Yonsei University Health System and who had 25(OH)D3 levels measured at the time of RTx. Patients were divided into two groups based on baseline 25(OH)D3 concentrations: group 1, 25(OH)D3 levels <10 ng/mL; and group 2, 25(OH)D3 levels ≥10 ng/mL.
RESULTS
Using multivariate regression models, 25(OH)D3, age, and erythrocyte-stimulating agent (ESA) dose were found to be significantly associated with hemoglobin (Hb) levels [25(OH)D3: β=0.263, p<0.001; age: β=0.122, p=0.010; ESA dose: β=-0.069, p=0.005]. In addition, logistic regression analysis revealed that patients in group 1 had a significantly higher risk for developing anemia (Hb level <10 g/dL) compared to group 2 patients, even after adjusting for potential risk factors for anemia (odds ratio=3.857; confidence interval=1.091-13.632; p=0.036).
CONCLUSION
25(OH)D3 deficiency was significantly associated with anemia in patients with ESRD. Randomized controlled trials are needed to determine whether vitamin D supplementation can improve anemia in these patients.

Keyword

Vitamin D deficiency; anemia; end-stage renal disease

MeSH Terms

Adult
Aged
Anemia/blood/*etiology
Calcifediol
Cross-Sectional Studies
Female
Hemoglobin A/analysis
Humans
Kidney Failure, Chronic/*complications
Kidney Transplantation
Male
Middle Aged
Odds Ratio
Prevalence
Regression Analysis
Risk Factors
Vitamin D/analogs & derivatives/blood
Vitamin D Deficiency/blood/*complications
Calcifediol
Hemoglobin A
Vitamin D

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