Yonsei Med J.  2016 Jul;57(4):963-967. 10.3349/ymj.2016.57.4.963.

Comparison of Predicted Total Lung Capacity and Total Lung Capacity by Computed Tomography in Lung Transplantation Candidates

Affiliations
  • 1Department of Radiology, Korea University Medical Center, Anam Hospital, Seoul, Korea.
  • 2Department of Thoracic and Cardiovascular Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
  • 4Department of Thoracic and Cardiovascular Surgery, Ajou University School of Medicine, Suwon, Korea. haamsj@aumc.ac.kr

Abstract

PURPOSE
Lung size mismatch is a major cause of poor lung function and worse survival after lung transplantation (LTx). We compared predicted total lung capacity (pTLC) and TLC measured by chest computed tomography (TLC(CT)) in LTx candidates.
MATERIALS AND METHODS
We reviewed the medical records of patients on waiting lists for LTx. According to the results of pulmonary function tests, patients were divided into an obstructive disease group and restrictive disease group. The differences between pTLC calculated using the equation of the European Respiratory Society and TLC(CT) were analyzed in each group.
RESULTS
Ninety two patients met the criteria. Thirty five patients were included in the obstructive disease group, and 57 patients were included in the restrictive disease group. pTLC in the obstructive disease group (5.50±1.07 L) and restrictive disease group (5.57±1.03 L) had no statistical significance (p=0.747), while TLC(CT) in the restrictive disease group (3.17±1.15 L) was smaller than that I the obstructive disease group (4.21±1.38 L) (p<0.0001). TLC(CT)/pTLC was 0.770 in the obstructive disease group and 0.571 in the restrictive disease group.
CONCLUSION
Regardless of pulmonary disease pattern, TLC(CT) was smaller than pTLC, and it was more apparent in restrictive lung disease. Therefore, we should consider the difference between TLC(CT) and pTLC, as well as lung disease patterns of candidates, in lung size matching for LTx.

Keyword

Lung transplantation; pulmonary function test; donor selection

MeSH Terms

Adolescent
Adult
Aged
Female
Humans
Lung/*diagnostic imaging/pathology/*physiopathology
Lung Diseases/diagnostic imaging/pathology/physiopathology/therapy
*Lung Transplantation
Male
Middle Aged
Organ Size
*Patient Selection
Retrospective Studies
*Tomography, X-Ray Computed
*Total Lung Capacity
Young Adult
Full Text Links
  • YMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr