Ann Lab Med.  2016 May;36(3):268-270. 10.3343/alm.2016.36.3.268.

Marked Increase of Circulating Double-Negative gammadelta T Cells in a Patient With Hydroa Vacciniforme-Like Lymphoma

• Shin SY
• Park CH
• Cho D
• Kim HJ
• Kim SH

• KMID: 2373540
• DOI: http://doi.org/10.3343/alm.2016.36.3.268

Abstract

No abstract available.

MeSH Terms

Child, Preschool
Female
Flow Cytometry
Humans
Hydroa Vacciniforme/*diagnosis/pathology
Immunophenotyping
Lymphocytosis/complications
Lymphoma/*diagnosis
Receptors, Antigen, T-Cell, gamma-delta/genetics/*metabolism
STAT3 Transcription Factor/genetics/metabolism
Sequence Analysis, DNA
Skin/metabolism
T-Lymphocytes/*metabolism
Receptors, Antigen, T-Cell, gamma-delta
STAT3 Transcription Factor

Figure

• 

  Fig. 1 Cytomorphological and immunophenotypic results for lymphocytes in the peripheral blood. (A) Large granular lymphocytes and small lymphocytes without significant atypia increased (Wright stain, ×1,000). (B) Surface CD3-positive/CD4-negative/CD8-negative/CD16-negative/CD56-negative/CD57-negative/T cell receptor (TCR)-γδ-positive T cells were noted.

Reference

1. Quintanilla-Martinez L, Ridaura C, Nagl F, Sáez-de-Ocariz M, Durán-McKinster C, Ruiz-Maldonado R, et al. Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma. Blood. 2013; 122:3101–3110. PMID: 23982171.

2. Kimura H, Miyake K, Yamauchi Y, Nishiyama K, Iwata S, Iwatsuki K, et al. Identification of Epstein-Barr virus (EBV)-infected lymphocyte subtypes by flow cytometric in situ hybridization in EBV-associated lymphoproliferative diseases. J Infect Dis. 2009; 200:1078–1087. PMID: 19698076.

3. Hirai Y, Yamamoto T, Kimura H, Ito Y, Tsuji K, Miyake T, et al. Hydroa vacciniforme is associated with increased numbers of Epstein-Barr virus-infected γδ T cells. J Invest Dermatol. 2012; 132:1401–1408. PMID: 22297643.

4. Kawabe S, Ito Y, Gotoh K, Kojima S, Matsumoto K, Kinoshita T, et al. Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases. Cancer Sci. 2012; 103:1481–1488. PMID: 22497716.

5. Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Peng Ng K, et al. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood. 2012; 120:3048–3057. PMID: 22859607.

6. Swerdlow SH, Campo E, editors. WHO classification of tumors of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC;2008.

7. Cho KH, Kim CW, Heo DS, Lee DS, Choi WW, Rim JH, et al. Epstein-Barr virus-associated peripheral T-cell lymphoma in adults with hydroa vacciniforme-like lesions. Clin Exp Dermatol. 2001; 26:242–247. PMID: 11422165.

8. Rashid A, Khurshid M, Ahmed A. T-cell large granular lymphocytic leukemia: 4 cases. Blood Res. 2014; 49:203–205. PMID: 25325044.

9. Kim TH, Lee JH, Kim YC, Lee SE. Hydroa vacciniforme-like lymphoma misdiagnosed as cutaneous lupus erythematosus. J Cutan Pathol. 2015; 42:229–231. PMID: 25488018.

10. Plaza JA, Sangueza M. Hydroa vacciniforme-like lymphoma with primarily periorbital swelling: 7 cases of an atypical clinical manifestation of this rare cutaneous T-cell lymphoma. Am J Dermatopathol. 2015; 37:20–25. PMID: 25162933.