Ann Lab Med.  2016 Jan;36(1):64-66. 10.3343/alm.2016.36.1.64.

A Rare Case of Pediatric T Lymphoblastic Leukemia With t(11;17)(q23;q21) Involving Mixed-Lineage Leukemia Gene Rearrangement

• Kim H
• Lee JK
• Lee JA
• Hong YJ
• Hong SI
• Jo HS
• Chang YH

• KMID: 2373500
• DOI: http://doi.org/10.3343/alm.2016.36.1.64

Abstract

No abstract available.

MeSH Terms

Adolescent
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 4
Gene Rearrangement
Histone-Lysine N-Methyltransferase/*genetics
Humans
Male
Myeloid-Lymphoid Leukemia Protein/*genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase

Figure

• 

  Fig. 1 Bone marrow karyogram at diagnosis and interphase FISH analysis after induction chemotherapy. (A) G-banded karyogram showing t(11;17)(q23;q21). The arrows denote the rearranged chromosomes. (B) FISH analysis using 11q23 break-apart probe revealed MLL rearrangement (158/200, 79%). Separation of a green and a red signal was observed.

Reference

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