Ann Lab Med.  2016 Jan;36(1):64-66. 10.3343/alm.2016.36.1.64.

A Rare Case of Pediatric T Lymphoblastic Leukemia With t(11;17)(q23;q21) Involving Mixed-Lineage Leukemia Gene Rearrangement

Affiliations
  • 1Department of Laboratory Medicine, Korea Cancer Center Hospital, Seoul, Korea. cyhlabo@kcch.re.kr
  • 2Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.
  • 3Radiological & Medico-Oncological Sciences, University of Science and Technology, Daejeon, Korea.
  • 4Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Abstract

No abstract available.


MeSH Terms

Adolescent
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 4
Gene Rearrangement
Histone-Lysine N-Methyltransferase/*genetics
Humans
Male
Myeloid-Lymphoid Leukemia Protein/*genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase

Figure

  • Fig. 1 Bone marrow karyogram at diagnosis and interphase FISH analysis after induction chemotherapy. (A) G-banded karyogram showing t(11;17)(q23;q21). The arrows denote the rearranged chromosomes. (B) FISH analysis using 11q23 break-apart probe revealed MLL rearrangement (158/200, 79%). Separation of a green and a red signal was observed.


Reference

1. Patrick K, Vora A. Update on biology and treatment of T-cell acute lymphoblastic leukaemia. Curr Opin Pediatr. 2015; 27:44–49. PMID: 25502893.
2. Meijerink JP. Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia. Best Pract Res Clin Haematol. 2010; 23:307–318. PMID: 21112032.
3. Pui CH, Schrappe M, Ribeiro RC, Niemeyer CM. Childhood and adolescent lymphoid and myeloid leukemia. Hematology Am Soc Hematol Educ Program. 2004; 118–145. PMID: 15561680.
4. Borowitz MJ, Chan JKC. T lymphoblastic leukaemia/lymphoma. In : Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC;2008. p. 176–178.
5. Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood. 2003; 102:262–268. PMID: 12637319.
6. Meyer C, Hofmann J, Burmeister T, Gröger D, Park TS, Emerenciano M, et al. The MLL recombinome of acute leukemias in 2013. Leukemia. 2013; 27:2165–2176. PMID: 23628958.
7. Yang JJ, Marschalek R, Meyer C, Park TS. Diagnostic usefulness of genomic breakpoint analysis of various gene rearrangements in acute leukemias: a perspective of long distance- or long distance inverse-PCR-based approaches. Ann Lab Med. 2012; 32:316–318. PMID: 22779077.
8. Strehl S, König M, Meyer C, Schneider B, Harbott J, Jäger U, et al. Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants. Genes Chromosomes Cancer. 2006; 45:1041–1049. PMID: 16897742.
9. Harrison CJ, Cuneo A, Clark R, Johansson B, Lafage-Pochitaloff M, Mugneret F, et al. Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants. Leukemia. 1998; 12:811–822. PMID: 9593286.
10. Beverstock GC, Hoekman K, Kluin-Nelemans JC, Wienhofer E. Reciprocal translocation, t(11;17)(q23-25;q21), in a patient with an immature ALL. Cancer Genet Cytogenet. 1986; 22:83–87. PMID: 3456831.
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