Korean J Gastroenterol.  2016 Apr;67(4):189-197. 10.4166/kjg.2016.67.4.189.

Comparative Study on Bowel Preparation Efficacy of Ascorbic Acid Containing Polyethylene Glycol by Adding Either Simethicone or 1 L of Water in Health Medical Examination Patients: A Prospective Randomized Controlled Study

• Yeo SH
• Kwak JH
• Kim YU
• Kwon TH
• Park JB
• Park JH
• Lee YK
• Lim YJ
• Yang CH

• KMID: 2373424
• DOI: http://doi.org/10.4166/kjg.2016.67.4.189

Abstract

BACKGROUND/AIMS
There are no studies that looked into the bubble eliminating efficacy of polyethylene glycol with ascorbic acid (PEGA), which has been one of the shortcomings of polyethylene glycol (PEG). In this study, we compared newly introduced PEGA regimen by adding either simethicone or 1 L of water.
METHODS
A prospective randomized controlled study was carried out at Dongguk Universtiy Gyeongju Hospital from July 2014 to September 2014. A total of 90 patients were randomly assigned to 3 groups; PEGA group (n=30) which served as control, simethicone addition group (n=30) to which simethicone 400 mg was additionally prescribed, and water addition group (n=30) to whom additional 1 L of water was given. Cleansing effectiveness, gas elimination efficacy, side effects, and patient satisfaction were compared between the groups.
RESULTS
PEGA group demonstrated the highest cleansing effectiveness, but there was no statistically significant difference among the groups. Simethicone addition group showed significantly lesser amount of bubbles than the other groups (2.57±2.05 vs. 1.10±1.83 vs. 2.60±2.84, p=0.017). The rates of side effects in each group were 20.00% vs. 16.77% vs. 53.33%. Water addition group had significantly more side effects than the PEGA group and the simethicone addition group (p=0.003). The patient satisfaction score of each group was 3.37±0.85 vs. 3.73±0.74 vs. 3.20±0.66 with simethicone addition group showing significantly higher satisfaction than water addition group (p=0.020).
CONCLUSIONS
PEGA bowel preparation agent showed satisfactory bowel cleansing despite the decrease in dosage, and addition of simethicone resulted in better bubble elimination.

Keyword

Colonoscopy; Bowel preparation solutions

MeSH Terms

Adult
Ascorbic Acid/*chemistry
Cathartics/adverse effects/chemistry/*pharmacology
Colon/*drug effects
Colonoscopy
Female
Humans
Male
Middle Aged
Patient Compliance
Polyethylene Glycols/adverse effects/*chemistry/pharmacology
Prospective Studies
Simethicone/*chemistry
Water/*chemistry
Ascorbic Acid
Cathartics
Polyethylene Glycols
Simethicone
Water

Figure

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  Fig. 1. Aronchick Bowel Preparation Scale (ABBS) score.

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  Fig. 2. Boston Bowel Preparation Scale (BBPS) score.

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  Fig. 3. Satisfaction of bowel preparation methods. We investigated the satisfaction with a five-point scale, extremely dissatisfied with one point and very satisfied with 5 points.

Reference

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