A Clinical Study of Multiple Non-melanoma Skin Cancers over 4 Years in a Single Institution Center

Kim, Min Sung; Kim, Yoon Soo; Na, Chan Ho; Shin, Bong Seok

Abstract

BACKGROUND
Non-melanoma skin cancers (NMSCs, basal cell carcinoma [BCC], and squamous cell carcinoma, [SCC]) are skin conditions, and the propensity of NMSCs to develop multiple tumors may be associated with some genodermatoses, arsenic poisoning, and chronic exposure to radiation or coal tar.
OBJECTIVE
To report our experience of treating multiple NMSCs and to investigate the clinical characteristics of NMSCs.
METHODS
We retrospectively evaluated 16 patients who had been diagnosed with NMSCs from May 2010 to December 2014.
RESULTS
The male-female sex ratio was 0.6:1 in the patients with multiple BCCs and SCCs. The most frequent age group was the seventh decade (75%). The mean patient age was 76.36 years. The most common involved site was the face, particularly the cheek (54.3%). Nodular BCCs were the most frequent (61.9%), followed by infiltrate BCCs (28.6%) and superficial BCCs (9.5%). Among the SCCs, the moderately differentiated SCCs were the most frequent (50%). More NMSCs were found on the left than on the right side of the head and neck areas in both sexes. Development of BCC (68.8%) was more frequent than that of SCC in sun-exposed areas.
CONCLUSION
In our study, differences in the demographic variables, such as age, sex, or residence were found between the patients with multiple BCCs and SCCs. The incidence of BCC has markedly increased, which is mainly because of the increment of aged people in their residence, along with environmental factors. Further cohort studies that include cumulative lifetime sun exposure and a large sample size are needed.