J Korean Gastric Cancer Assoc.  2006 Mar;6(1):31-35.

Primary Adenosquamous Carcinoma of the Stomach

Affiliations
  • 1Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea. sungkimm@smc.samsung.co.kr
  • 2Department of Surgery, Konkuk University College of Medicine Seoul, Korea.

Abstract

PURPOSE: A primary adenosquamous carcinoma of the stomach is relatively rare, accounting for only about 0.5% of all gastric cancers. However, its histopathologic characteristics are still unclear, and the most appropriate form of therapy has not been established yet.
MATERIALS AND METHODS
We retrospectively reviewed the clinicopathologic features of 8 patients with pathologically confirmed primary adenosquamous carcinomas out of 8,268 patients who underwent gastric cancer surgery at Samsung Medical Center between September 1994 and December 2004.
RESULTS
The median age of the 8 patients was 49 (41~69) years, and the male : female ratio was 5 : 3. In 3 patients, the tumor was located at the mid body of the stomach, and in 5 patients, at the lower body or antrum. The tumor sizes were 2.5~8 cm. Seven patients showed metastases to the regional lymph nodes. The UICC stage distribution were: 5 stage II, 2 stage III, and 1 stage IV. In the stage IV patient, a palliative gastrojejunostomy was performed, and he died 5 months after surgery. Of the 7 patients who underwent a radical gastrectomy and adjuvant chemotheratpy, the median survival was 34 (12~66) months, 2 patients died of cancer recurrence, and 4 patients are being followed up without evidence of recurrence.
CONCLUSION
As for an adenocarcinoma of the stomach, a radical gastrectomy including regional lymph node dissection and postoperative adjuvant therapy should be performed for appropriate treatment of an adenosquamous carcinoma of the stomach.

Keyword

Gastric cancer; Adenosquamous carcinoma; Gastrectomy; Prognosis

MeSH Terms

Adenocarcinoma
Carcinoma, Adenosquamous*
Female
Gastrectomy
Gastric Bypass
Humans
Lymph Node Excision
Lymph Nodes
Male
Neoplasm Metastasis
Prognosis
Recurrence
Retrospective Studies
Stomach Neoplasms
Stomach*
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