J Gastric Cancer.  2012 Dec;12(4):217-222.

Clinical Correlation between Gastric Cancer Type and Serum Selenium and Zinc Levels

• Ji JH
• Shin DG
• Kwon Y
• Cho DH
• Lee KB
• Park SS
• Yoon J

Abstract

PURPOSE
We conducted this study to study the clinical correlation between the characteristics of gastric cancer and serum selenium and zinc levels.
MATERIALS AND METHODS
The following data were measured in the baseline serum selenium and zinc levels of 74 patients with curative gastrectomy subsequent to confirmed gastric cancer, from March 2005 to August 2012.
RESULTS
Among the 74 gastric cancer patients, 53 patients were male. Mean serum selenium and zinc levels were 118.7+/-33.1 ug/L and 72.2+/-24.3 ug/dl, respectively. Seven patients (9.5%) showed lower selenium level, and 33 patients (44.6%) showed lower zinc level. Serum Selenium level was 99.1+/-31.8 ug/L in cardia cancer group (10 cases) and 121.8+/-32.4 ug/L in non-cardia cancer group (64 cases)(P=0.044). According to tumor gross type, zinc level was 78.7+/-29.6 ug/dl in early gastric cancer (33) and 66.9+/-17.8 ug/dl in advanced gastric cancer (41) (P=0.064).
CONCLUSIONS
The serum selenium level was highly correlated with the location of gastric cancer. The serum zinc level was lower in advanced gastric cancer.

Keyword

Stomach neoplasms; Selenium; Zinc

MeSH Terms

Cardia
Gastrectomy
Humans
Male
Selenium
Stomach Neoplasms
Zinc
Selenium
Zinc

Figure

• 

  Fig. 1 Comparison of (A) selenium and (B) zinc level with two clinical feature of gastric cancer (mean). EGC = early gastric cancer; AGC = advanced gastric cancer. *P=0.009 (tow extreme value of AGC and EGC in Cardia group).

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