J Gastric Cancer.  2014 Mar;14(1):58-62.

A Rare Case of Primary Squamous Cell Carcinoma of the Stomach and a Review of the 56 Cases Reported in Japan

• Wakabayashi H
• Matsutani
• Fujita I
• Kanazawa Y
• Nomura T
• Hagiwara N
• Hosone M
• Katayama H
• Uchida E

Abstract

We report an extremely rare case of primary squamous cell carcinoma of the stomach. A 69-year-old man was admitted to our hospital with a 2-month history of dysphagia and tarry stools. Endoscopic examination revealed a cauliflower-shaped protruding mass along the lesser curvature of the gastric cardia. Biopsy of the lesion revealed squamous cell carcinoma of the stomach. Computed tomography revealed a thickened stomach wall and a mass protruding into the gastric lumen. Total gastrectomy with splenectomy, distal pancreatectomy, and Roux-en-Y reconstruction was performed, together with a lower thoracic esophagectomy via a left thoracotomy. Histopathological examination of the specimen revealed well-differentiated squamous cell carcinoma of the stomach. Postoperative follow-up was uneventful for the first 18 months. However, multiple liver metastases and para-aortic lymph node metastasis developed subsequently. Despite systemic combination chemotherapy, the patient died because of progression of the recurrent tumors. Here, we review the characteristics of 56 cases of gastric squamous cell carcinoma reported in Japan.

Keyword

Gastric cancer; Squamous cell carcinoma

MeSH Terms

Aged
Biopsy
Carcinoma, Squamous Cell*
Cardia
Deglutition Disorders
Drug Therapy, Combination
Esophagectomy
Follow-Up Studies
Gastrectomy
Humans
Japan*
Liver
Lymph Nodes
Neoplasm Metastasis
Pancreatectomy
Splenectomy
Stomach Neoplasms
Stomach*
Thoracotomy

Figure

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  Fig. 1 (A) Gastrointestinal endoscopic examination showing a cauliflower-shaped protruding mass involving the lesser curvature of the gastric cardia. (B) An upper gastrointestinal barium series showing an elevated mass arising in the lesser curvature of the gastric cardia (arrows).

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  Fig. 2 A computed tomography showing a heterogeneous mass approximately 5.0 cm in diameter arising in the gastric cardia (arrows).

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  Fig. 3 (A) Macroscopic examination of the resected specimens showing an ulcerated mass, measuring 7.5×9.0 cm, in the gastric cardia along the lesser curvature (arrows). (B) Histopathological examination showing a well-differentiated squamous cell carcinoma (H&E, ×200).

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