J Biomed Transl Res.  2016 Jun;17(2):26-29. 10.12729/jbtr.2016.17.2.026.

Therapeutic trials to evaluate the efficacy of topical Clotrimazole and Nystatin on clinical cases of otitis externa in dogs caused by Malassezia pachydermatis in district Lahore and its suburbs in Pakistan

• Kashif M
• Rizwan M
• Durrani AZ
• Nasir A
• Kim G

• KMID: 2368702
• DOI: http://doi.org/10.12729/jbtr.2016.17.2.026

Abstract

Malassezia pachydermatis (M. pachydermatis) otitis is an important infectious disease of dogs throughout the world. In the present study, the presence, diagnosis, clinical signs and chemotherapy of M. pachydermatis were studied in clinical otitic dogs of Lahore and its suburbs. During two-year study period, a total of 200 ear cerumen samples from otitic dogs were examined microscopically. Of these, 46 (23%) were found positive for M. pachydermatis. The difference in the prevalence of infection between the pendulous ear and erected ear dogs as well as sex predilection was found non-significant (P>0.05). However, a significantly (P<0.05) higher prevalence (86.90%) was recorded in dogs of more than one years of age group. The animals determined positive for the M. pachydermatis were divided into two groups (A and B) and treated with Clotrimazole and Nystatin, respectively. Efficacy of both the antifungals was evaluated on the basis of reversal of clinical signs scoring and cytological examinations at 7, 14, 21-day post treatment. The overall efficacy of Clotrimazole and Nystatin was 73% and 68%, respectively. Clotrimazole showed better results as compared to Nystatin in accomplishing cure rate from mycological infection. It was concluded that M. pachydermatis is a significant cause of otitis in dogs wherein Clotrimazole proves to be a more effective drug in eliminating the infection in the affected Dogs.

Keyword

otitis; malassezia pachydermatis; clotrimazole; nystatin; dogs

MeSH Terms

Animals
Cerumen
Clotrimazole*
Communicable Diseases
Diagnosis
Dogs*
Drug Therapy
Ear
Humans
Malassezia*
Nystatin*
Otitis Externa*
Otitis*
Pakistan*
Prevalence
Clotrimazole
Nystatin