J Biomed Transl Res.
2016 Dec;17(4):91-96. 10.12729/jbtr.2016.17.4.091.
Tumor necrosis factor-α (TNF-α) polymorphism (-308, G/A) and autoimmune diseases: an updated meta-analysis
- Affiliations
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- 1Herbal Crop Utilization Research Team, Department of Medicinal Crop Research Institute, Republic of Korea.
- 2Department of Biomedical Laboratory Science, College of Health Sciences, Shinhan University, Uijeongbu 11644, Korea. kbcho@shinhan.ac.kr
- KMID: 2368689
- DOI: http://doi.org/10.12729/jbtr.2016.17.4.091
Abstract
- Previous studies have investigated the potential relationship between promoter polymorphism (-308, G/A) of tumor necrosis factor (TNF)-α and various autoimmune diseases. However, results from published data were inconclusive. To verify relationship between TNF-α polymorphism (-308, G/A) and susceptibility to autoimmune diseases such as vitiligo, celiac disease, and rheumatoid arthritis, we have performed a metaanalysis with all relevant articles before October 2016. The electronic search of PubMed, google, and Embase databases was performed to identify eligible studies investigating the relationship of TNF-α polymorphism with autoimmune diseases including vitiligo, celiac disease, and rheumatoid arthritis. Genotype frequency data of TNF-α polymorphism (-308, G/A) were extracted and the meta analysis was performed by Comprehensive meta-analysis program with odds ratio (OR) and 95% confidence intervals (95% CI). Genotype models were applied with dominant and recessive models and allele model analyzed. The final analysis included 37 publication papers with a total of 6,102 autoimmune disease patients and 6,987 control subjects. In result, a statistical significant correlation between TNF-α polymorphism (-308, G/A) and susceptibility to autoimmune disease was not detected in our meta-analysis (p>0.05 in all models). Our results suggest that the TNF-α polymorphism might not be related to the development of autoimmune disease. If further results in larger studies would be accumulated in the future, this relationship would be clarified.
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