Ann Dermatol.  2017 Feb;29(1):121-123. 10.5021/ad.2017.29.1.121.

Increased Serum High Mobility Group Box 1 (HMGB1) Concentration and the Altered Expression of HMGB1 and Its Receptor Advanced Glycation Endproducts in Pemphigus

• Li JY
• Lu YH
• Zhang LW
• Zhou PM
• Chen T

• KMID: 2368046
• DOI: http://doi.org/10.5021/ad.2017.29.1.121

Abstract

No abstract available.

MeSH Terms

HMGB1 Protein*
Pemphigus*
HMGB1 Protein

Figure

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  Fig. 1 Serum levels of high mobility group box 1 (HMGB1) were determined by enzyme-linked immunosorbent assay. (A) Serum levels of HMGB1 were obtained from 27 patients with pemphigus, 22 with bullous pemphigoid and 32 control subjects. Serum HMGB1 levels in patients with pemphigus were significantly higher than those in control subjects. p-values are based on the Mann-Whitney U test. (B) Wilcoxon signed ranks test for paired data showed that serum HMGB1 levels of 16 patients with pemphigus before treatment were significantly higher than those after treatment.

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  Fig. 2 Tissue samples were obtained from 15 patients with pemphigus, 12 patients with bullous pemphigoid and 15 control subjects. The expression of high mobility group box 1 (HMGB1) and receptor advanced glycation endproducts (RAGE) in the skin was detected by immunohistochemistry. The skin expression of RAGE was negative in controls, was strong positive in pemphigus patients and weak positive in bullous pemphigoid patients. Inset: HMGB1 expressed in cytoplasm of patients with pemphigus. Scale bars=50 µm.

Reference

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