Biomol Ther.  2017 Jan;25(1):44-56. 10.4062/biomolther.2016.128.

β-Adrenergic Receptor and Insulin Resistance in the Heart

• Mangmool S
• Denkaew T
• Parichatikanond W
• Kurose H

• KMID: 2367618
• DOI: http://doi.org/10.4062/biomolther.2016.128

Abstract

Insulin resistance is characterized by the reduced ability of insulin to stimulate tissue uptake and disposal of glucose including cardiac muscle. These conditions accelerate the progression of heart failure and increase cardiovascular morbidity and mortality in patients with cardiovascular diseases. It is noteworthy that some conditions of insulin resistance are characterized by up-regulation of the sympathetic nervous system, resulting in enhanced stimulation of β-adrenergic receptor (βAR). Over-stimulation of βARs leads to the development of heart failure and is associated with the pathogenesis of insulin resistance in the heart. However, pathological consequences of the cross-talk between the βAR and the insulin sensitivity and the mechanism by which βAR over-stimulation promotes insulin resistance remain unclear. This review article examines the hypothesis that βARs over-stimulation leads to induction of insulin resistance in the heart.

Keyword

β-adrenergic receptor; β-blockers; G protein-coupled receptor kinase; Heart diseases; Insulin resistance; Protein kinase A

MeSH Terms

Cardiovascular Diseases
Cyclic AMP-Dependent Protein Kinases
Glucose
Heart Diseases
Heart Failure
Heart*
Humans
Insulin Resistance*
Insulin*
Mortality
Myocardium
Sympathetic Nervous System
Up-Regulation
Cyclic AMP-Dependent Protein Kinases
Glucose
Insulin