J Cancer Prev.
2016 Dec;21(4):288-293. 10.15430/JCP.2016.21.4.288.
The Evaluation of p53 Polymorphism at Codon 72 and Association With Breast Cancer in Iran: A Systematic Review and Meta-analysis
- Affiliations
-
- 1Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran.
- 2Clinical Research Development Center, Imam Ali and Taleghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran. afsharshahmohammadi@yahoo.com
- 3Cancer Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
- 4Province Health Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
- KMID: 2367567
- DOI: http://doi.org/10.15430/JCP.2016.21.4.288
Abstract
- BACKGROUND
Breast cancer is the most common cancer among women in Iran and the world. Multiple environmental factors and genetic variations such as genetic polymorphisms are of its main causes. p53 gene plays an important role in conserving and sustaining the genome as a tumor suppressing gene. Change and polymorphism at codon 72 of p53 gene are correlated with increased risk of lung, mouth, endometrial, prostate, and colorectal cancers, and could be considered an indicator of susceptibility to breast cancer.
METHODS
Twelve studies (1,190 cases and 1,145 control studies with evaluation of three types of Arg/Arg, Arg/Pro, and Pro/Pro genotypes) have been conducted using keywords, such as polymorphism at codon 72, gene p53 polymorphisms, and the relation between polymorphisms and breast cancer, from databases in Iran, including Magiran, Medlibe, Sid, and Iranmedex, as well as Latin databases such as PubMed, Google Scholar, Science Direct, and Scopus.
RESULTS
The OR for Arg/Arg is 1.58 (95% CI: 2.45 to 1.01), the OR for Arg/Pro is 0.75 (95% CI: 1.10 to 0.51), and the OR for Pro/Pro is 0.62 (95% CI: 0.93 to 0.42). p53 gene polymorphism at codon 72 is statistically significant in Arg/Arg and Pro/Pro genotypes.
CONCLUSIONS
Arg/Arg genotype can be considered as a risk factor for breast cancer, and Pro/Pro genotype can be accounted for as a protective factor against breast cancer.
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