Asian Oncol Nurs.  2016 Dec;16(4):242-250. 10.5388/aon.2016.16.4.242.

Anxiety and Depression as Predictive Factors for Quality of Life in Patients with Advanced Gastrointestinal Cancer

Affiliations
  • 1Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea. sook3529@hanmail.net
  • 2College of Nursing, Chonbuk Research Institute of Nursing Science, Chonbuk National University, Jeonju, Korea.
  • 3Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea.
  • 4Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Korea.

Abstract

PURPOSE
The purpose of the present study was to assess factors associated with quality of life (QOL) and to determine whether anxiety and depression are predictive of QOL in patients with advanced gastrointestinal cancer at initial diagnosis and during the treatment process.
METHODS
One hundred and twenty patients with gastrointestinal cancer requiring palliative chemotherapy were enrolled.
RESULTS
At baseline, depression, performance status, and anxiety accounted for 55.0% (p<.001) of the variance in global health status score, depression accounted for 22.0% (p<.001) of the variance in functional scales score, and anxiety accounted for 19.0% (p<.001) of the variance in symptom scales score. At 3 months, depression, pain, and performance status accounted for 72.0% (p<.001) of the variance in global health status score, 76.0% (p<.001) of the variance in functional scales score, and 74.0% (p<.001) of the variance in symptom scales score.
CONCLUSION
Anxiety and depression were significant predictive factors of QOL in patients with advanced gastrointestinal cancer. Depression and performance status were significant predictive factors of QOL at both baseline and 3 months, and anxiety and pain were significant predictive factors of QOL at baseline and 3 months, respectively.

Keyword

Anxiety; Cancer; Depression; Gastrointestinal; Quality of Life

MeSH Terms

Anxiety*
Depression*
Diagnosis
Drug Therapy
Gastrointestinal Neoplasms*
Global Health
Humans
Quality of Life*
Weights and Measures

Figure

  • Fig. 1 Flow diagram showing patient selection.


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