Urogenit Tract Infect.  2016 Dec;11(3):103-108. 10.14777/uti.2016.11.3.103.

Serum CCL11 Levels in Benign Prostatic Hyperplasia and Prostate Cancer

• Kim KS
• Moon HS
• Park SY
• Hwang HS
• Kim JH
• Kim SS
• Han IH
• Kim KJ
• Noh CS
• Ryu JS

• KMID: 2366146
• DOI: http://doi.org/10.14777/uti.2016.11.3.103

Abstract

PURPOSE
CC-chemokine ligand 11 (CCL11; eotaxin-1), an eosinophil chemoattractant chemokine, has been proposed as a serum marker for prostate cancer (PCa) by two research groups. We investigated the usefulness of CCL11 in diagnosing prostatic diseases, such as benign prostatic hyperplasia (BPH) and PCa.
MATERIALS AND METHODS
CCL11 was measured in the sera of 139 men with BPH, 44 men with PCa, and 45 control men attending an outpatient health-screening clinic. A commercial enzyme-linked immunosorbent assay kit was used to measure CCL11.
RESULTS
CCL11 concentrations were significantly higher in men with BPH and PCa than in normal men (72.9±3.15 and 80.0±4.91 pg/ml vs. 57.6±8.24). In addition, a receiver operating characteristic (ROC) analysis of serum CCL11 levels showed that the areas under the ROC curves were 0.661 (p=0.001) and 0.654 (p=0.012) for BPH and PCa, respectively, compared with normal men.
CONCLUSIONS
CCL11 may be helpful in diagnosing prostatic diseases, such as BPH and PCa.

Keyword

Chemokine CCL11; Prostatic hyperplasia; Prostatic neoplasms

MeSH Terms

Biomarkers
Chemokine CCL11
Enzyme-Linked Immunosorbent Assay
Eosinophils
Humans
Male
Outpatients
Passive Cutaneous Anaphylaxis
Prostate*
Prostatic Diseases
Prostatic Hyperplasia*
Prostatic Neoplasms*
ROC Curve
Biomarkers
Chemokine CCL11

Figure

• 

  Fig. 1. Serum CC-chemokine ligand 11 (CCL11) levels (pg/ml) in men without prostatic disease (normal) and patients with benign prostatic hyperplasia (BPH) and prostate cancer (PCa). (A) CCL11 differed significantly between the three group (Kruskal-Wallis test, ∗p-value=0). (B) CCL11 levels are significantly higher in prostatic disease (BPH or PCa) than in normal men (Mann-Whitney test, ∗p-value=0.001). (C) CCL11 levels in patients with prostate cancers with different Gleason scores (GS).

• 

  Fig. 2. Receiver operating characteristic (ROC) curves for CC-chemokine ligand 11 (CCL11). (A) ROC curves distinguishing between benign prostatic hyperplasia (BPH) and no disease. The optimal cutoff of the CCL11 levels for distinguishing BPH from control (no disease) was determined as 53.1955 using the ROC curve (sensitivity=0.691, 1-specificity=0.422). Area under the curve (AUC) was 0.661, and 95% confidence interval (CI) was 0.560-0.762, p=0.001. (B) ROC curve distinguishing between prostate cancer (PCa) and no disease. The optimal cutoff of the CCL11 levels for distinguishing PCa from control (no disease) was determined as 52.6195 using the ROC curve (sensitivity=0.659, 1-specificity=0.467). AUC was 0.654, and 95% CI was 0.540-0.768, p=0.012. (C) ROC curve distinguishing between prostatic disease and no disease. The optimal cutoff of the CCL11 levels for distinguishing prostatic diseases from no disease was determined as 53.1955 using the ROC curve (sensitivity=0.683, 1-specificity=0.422). AUC was 0.659, and 95% CI was 0.562-0.757, p=0.001.

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