Kosin Med J.  2016 Dec;31(2):122-133. 10.7180/kmj.2016.31.2.122.

Prognostic Significance of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Diffuse Large B-Cell Lymphoma Patients Treated with R-CHOP

• Park LC
• Lee HS
• Lee EM
• Shin SH
• Kim YS

• KMID: 2365237
• DOI: http://doi.org/10.7180/kmj.2016.31.2.122

Abstract

OBJECTIVES
The both values of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) were reported as indexes of systemic inflammation and readily available and inexpensive prognostic markers in patients with solid cancer. The objective of this study was to clarify whether the NLR and PLR were significant prognostic markers in Korean diffuse large B-cell lymphoma (DLBCL) patients treated with R-CHOP as a first line therapy.
METHODS
We retrospectively collected the clinical data of ninety nine DLBCL patients treated with R-CHOP from 2004 to 2012 and analyzed. NLR and PLR were calculated from complete blood count (CBC) and differential leukocyte count.
RESULTS
In univariate analysis, NLR was significantly associated with 5-year progression free survival(PFS) rate (P= 0.039), but not significantly associated with 5-year overal survival (OS) rate (P= 0.276). PLR was not significantly associated with 5-year PFS (P= 0.632) and OS rate (P= 0.855). In multivariate analysis, NLR was not a significant independent prognostic factor for 5-year PFS (P= 0.415) and OS rate (P= 0.991).
CONCLUSION
The NLR can be considered a useful predictor of survival outcome. The PLR is not a valid predictor of survival outcome.

Keyword

DLBCL; NLR; PLR; Prognostic factor

MeSH Terms

B-Lymphocytes*
Blood Cell Count
Blood Platelets*
Humans
Inflammation
Leukocyte Count
Lymphocytes*
Lymphoma, B-Cell*
Multivariate Analysis
Neutrophils*
Retrospective Studies

Figure

• 

  Fig. 1. Five years progression free survival curves and overall survival curves according to Neutrphil/lymphocyte ratio in patients with diffuse large B-cell lymphoma. a. Five years progression free survival curves b. Five years overall survival curves

• 

  Fig. 2. Five years progression free survival curves and overall survival curves according to Platelet/lymphocyte ratio in patients with diffuse large B-cell lymphoma. a. Five years progression free survival curves b. Five years overall survival curves

Reference

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