Clin Exp Reprod Med.  2016 Dec;43(4):185-192. 10.5653/cerm.2016.43.4.185.

Chronic endometritis and infertility

• Park HJ
• Kim YS
• Yoon TK
• Lee WS

• KMID: 2364654
• DOI: http://doi.org/10.5653/cerm.2016.43.4.185

Abstract

Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease. However, the relationship between CE and infertility-related conditions such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. In this study, we reviewed the literature on the pathophysiology of CE and how it may be associated with infertility, as well as the literature regarding the diagnosis and treatment of CE. In addition, we discuss the value of hysteroscopic procedures in the diagnosis and treatment of CE.

Keyword

Chronic endometritis; Endometrium; Fertilization in vitro; Hysteroscopy; Repeated implantation failure

MeSH Terms

Abortion, Habitual
Diagnosis
Endometritis*
Endometrium
Female
Fertilization in Vitro
Hysteroscopy
Immune System
Infertility*
Pregnancy
Prevalence