Ann Lab Med.  2015 Jan;35(1):152-154. 10.3343/alm.2015.35.1.152.

The First Case Report of Composite Bone Marrow Involvement by Simultaneously Developed Peripheral T-Cell Lymphoma, Not Otherwise Specified, and Diffuse Large B-Cell Lymphoma

• Kim HK
• Park CJ
• Jang S
• Cho YU
• Park SH
• Choi J
• Park CS
• Huh J
• Chung YH
• Lee JH

• KMID: 2363166
• DOI: http://doi.org/10.3343/alm.2015.35.1.152

Abstract

No abstract available.

MeSH Terms

Antibodies, Monoclonal, Murine-Derived/therapeutic use
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
B-Cell-Specific Activator Protein/metabolism
Bone Marrow/metabolism/*pathology
Cyclophosphamide/therapeutic use
Doxorubicin/therapeutic use
Endoscopy, Digestive System
Female
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Genetic Loci
Humans
Liver/metabolism/pathology
Lymphocytes/cytology/immunology
Lymphoma, Large B-Cell, Diffuse/complications/*diagnosis/drug therapy
Lymphoma, T-Cell, Peripheral/complications/*diagnosis/drug therapy
Middle Aged
Prednisone/therapeutic use
Receptors, Antigen, T-Cell, gamma-delta/genetics
Tomography, X-Ray Computed
Vincristine/therapeutic use
Antibodies, Monoclonal, Murine-Derived
B-Cell-Specific Activator Protein
Cyclophosphamide
Doxorubicin
Prednisone
Receptors, Antigen, T-Cell, gamma-delta
Vincristine

Figure

• 

  Fig. 1 Bone marrow biopsy after 6 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) combination chemotherapy. (A, B) Neoplastic B lymphocytes infiltrating in an interstitial pattern was immunohistochemically analyzed by anti-PAX5 antibody (A, ×100; B, ×1,000). (C, D) Neoplastic T lymphocytes infiltrating with a peritrabecular or interstitial pattern was immunohistochemically analyzed by anti-CD3 antibody (C, ×100; D, ×1,000).

• 

  Fig. 2 T cell receptor gamma locus (TRG) rearrangement analyzed by using BIOMED-2 multiplex PCR. Horizontal axis represents amplicon size (base pairs) and vertical axis represents fluorescence intensity. (A) A monoclonal TRG rearrangement was detected at 170 bp in the liver sample. (B) Both a larger peak (160 bp) and a smaller peak (170 bp) were observed in the bone marrow aspirate sample by GeneScan analysis of the PCR results.

Reference

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