Ann Lab Med.  2015 Jan;35(1):149-151. 10.3343/alm.2015.35.1.149.

Simultaneous Occurrence of Angioimmunoblastic T-cell Lymphoma and Plasma Cell Leukemia

• Jang MA
• Lee ST
• Kim HJ
• Kim S
• Kim SH

• KMID: 2363165
• DOI: http://doi.org/10.3343/alm.2015.35.1.149

Abstract

No abstract available.

MeSH Terms

Aged
Humans
Leukemia, Plasma Cell/complications/*diagnosis/pathology
Leukocytosis
Lymph Nodes/pathology
Lymphoma, T-Cell/complications/*diagnosis/pathology
Male
Paraproteinemias/complications
Polymerase Chain Reaction
Receptors, Antigen, T-Cell, gamma-delta/genetics/metabolism
Tomography, X-Ray Computed
Receptors, Antigen, T-Cell, gamma-delta

Figure

• 

  Fig. 1 Histologic findings of the bone marrow biopsy. (A) Bone marrow biopsy showed nodular lymphocytic infiltrates with malignant cells (Hematoxylin and Eosin, ×400). (B) The malignant cells were positive for CD3 (×400). (C, D) Plasma cells expressed κ light chain restriction. Immunohistochemical staining with anti-κ (C) and anti-λ (D) (×400).

• 

  Fig. 2 Flow cytometry analysis of circulating lymphocytes. (A) and (B) CD45 and side scatter (SSC) gating: T-cells were positive for CD3, and B-cells were positive for CD19. (C) and (D) The CD19+ B-cells expressed high density of CD38 and cytoplasmic monoclonal immunoglobulin light chain κ proteins suggestive of plasma cells. (E) and (F) CD3+ T-cells were negative for CD7 and positive for CD4 suggesting the presence of malignant T-cells with immunophenotypic variation.Abbreviations: SSC, side scatter; cKAPPA, cytoplasmic immunoglobulin κ; cLAMBDA, cytoplasmic immunoglobulin λ.

Reference

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