Clin Mol Hepatol.
2016 Mar;22(1):140-145. 10.3350/cmh.2016.22.1.140.
Magnetization-tagged MRI is a simple method for predicting liver fibrosis
- Affiliations
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- 1Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea. radpms@yuhs.ac
- 2Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, USA.
- 3Tachkent Medical Academy, Tachkent, Uzbekistan.
- KMID: 2363031
- DOI: http://doi.org/10.3350/cmh.2016.22.1.140
Abstract
- BACKGROUND/AIMS
To assess the usefulness of magnetization-tagged magnetic resonance imaging (MRI) in quantifying cardiac-induced liver motion and deformation in order to predict liver fibrosis.
METHODS
This retrospective study included 85 patients who underwent liver MRI including magnetization-tagged sequences from April 2010 to August 2010. Tagged images were acquired in three coronal and three sagittal planes encompassing both the liver and heart. A Gabor filter bank was used to measure the maximum value of displacement (MaxDisp) and the maximum and minimum values of principal strains (MaxP1 and MinP2, respectively). Patients were divided into three groups (no fibrosis, mild-to-moderate fibrosis, and significant fibrosis) based on their aspartate-aminotransferase-to-platelet ratio index (APRI) score. Group comparisons were made using ANOVA tests.
RESULTS
The patients were divided into three groups according to APRI scores: no fibrosis (≤0.5; n=41), moderate fibrosis (0.5-1.5; n=23), and significant fibrosis (>1.5; n=21). The values of MaxDisp were 2.9±0.9 (mean±SD), 2.3±0.7, and 2.1±0.6 in the no fibrosis, moderate fibrosis, and significant fibrosis groups, respectively (P<0.001); the corresponding values of MaxP1 were 0.05±0.2, 0.04±0.02, and 0.03±0.01, respectively (P=0.002), while those of MinP2 were -0.07±0.02, -0.05±0.02, and -0.04±0.01, respectively (P<0.001).
CONCLUSIONS
Tagged MRI to quantify cardiac-induced liver motion can be easily incorporated in routine liver MRI and may represent a helpful complementary tool in the diagnosis of early liver fibrosis.
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