Ann Dermatol.  2002 Mar;14(1):28-30. 10.5021/ad.2002.14.1.28.

Chronic Hydroxyurea-induced Dermatomyositis-like Eruption Showing Epidermal Dysmaturation

• Park JH
• Kim CD
• Ryoo YW
• Kim BC
• Lee KS

• KMID: 2362382
• DOI: http://doi.org/10.5021/ad.2002.14.1.28

Abstract

Hydroxyurea is an effective treatment for a variety of myeloproliferative disodrers. A distinct cutaneous reaction to long-term administration of hydroxyurea has been characterized and designated hydroxyurea dermopathy. Epidermal dysmaturation refers to histologic changes that may be observed in the epidermis after any significant cytoreductive therapy. We report a patient with hydroxyurea-induced dermatomyositis-like eruption showing epidermal dysmaturation who developed an erythematous scaly patches on the dorsal aspects of the hands while on long-term administration of hydroxyurea for chronic myelogenous leukemia.

Keyword

Hydroxyurea; Epidermal dysmaturation; Dermatomyositis

MeSH Terms

Dermatomyositis
Epidermis
Hand
Humans
Hydroxyurea
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Hydroxyurea