J Korean Burn Soc.  2016 Dec;19(2):67-72. 10.0000/jkbs.2016.19.2.67.

Risk Factors Associated with Rhabdomyolysis in Acute Carbon Monoxide Poisoning

• Han G
• Jang YS
• Jang JH
• Lim YS
• Yang HJ

• KMID: 2361629
• DOI: http://doi.org/10.0000/jkbs.2016.19.2.67

Abstract

PURPOSE
The aim of this study was to determine the risk factors for rhabdomyolysis in patients with carbon monoxide (CO) poisoning.
METHODS
This was a retrospective study on patients with CO poisoning who visited the emergency department from January 1, 2014 to December 31, 2015. We compared clinical variables between patients with and without rhabdomyolysis.
RESULTS
Among 120 patients who were included to this study, 108 patients exhibited normal value of CPK (creatine phosphokinase), and 12 patients were diagnosed as rhabdomyolysis. Sources of CO, duration of CO exposure, initial GCS (Grasgow coma scale), initial systolic and diastolic blood pressure, initial body temperature and AKI (Acute kidney injury) were showed significant difference between patients who developed rhabdomyolysis and patients who did not. In addition, initial white blood cell counts, troponin I level and carboxyhemoglobin (COHb) level were more higher in rhabdomyolysis group. pH and initial bicarbonate level were more lower. Duration of CO exposure (Odds ratio, 1.011; 95% confidence interval, 1.002∼1.020, P=0.021)was found to be only risk factor for rhabdomyolysis by logistic regression analysis.
CONCLUSION
Duration of CO exposure is potential risk factor of rhabdomyolysis development in CO poisoning.

Keyword

Carbon monoxide poisoning; Rhabdomyolysis; Duration of CO exposure

MeSH Terms

Blood Pressure
Body Temperature
Carbon Monoxide Poisoning*
Carbon Monoxide*
Carbon*
Carboxyhemoglobin
Coma
Emergency Service, Hospital
Humans
Hydrogen-Ion Concentration
Kidney
Leukocyte Count
Logistic Models
Poisoning
Reference Values
Retrospective Studies
Rhabdomyolysis*
Risk Factors*
Troponin I
Carbon
Carbon Monoxide
Carboxyhemoglobin
Troponin I