Korean J Urol Oncol.  2016 Aug;14(2):63-68. 10.22465/kjuo.2016.14.2.63.

Analysis of NF-κB and Clinical Prognostic Factors in Clear Cell Renal Cell Carcinoma

• Lee Y
• Choi J
• Lee DG
• Yoo KH
• Min GE
• Lee HL
• Won KY
• Lim SJ

• KMID: 2361565
• DOI: http://doi.org/10.22465/kjuo.2016.14.2.63

Abstract

PURPOSE
A multi-subunit transcription factor NF-κB is associated with anti-apoptotic signals in several cancers including renal cell carcinoma (RCC). In this study, we investigated whether the expression levels of the NF-κB were related to the clinical properties of human renal cell carcinoma such as nuclear grade, TNM stage, and recurrence free survival.
MATERIALS AND METHODS
Patients who were diagnosed with clear cell RCC between January 2006 and February 2013 were included. Clinicopathological data and survival were investigated. The expressions of NF-κB were investigated by performing immunohistochemical staining on 61 clear cell RCC. The expression levels of NF-κB were divided two groups by the expression levels.
RESULTS
Results on the expression of NF-κB were not significant. Analysis of NF-κB expressions is not associated with any of the clinical properties including age, nuclear grade and TNM stage (p=0.613, p=0.059, p=0.107, p=0.570, and p=0.760, respectively). Also, a statistically correlation was not observed between recurrence free survival and NF-κB expression levels (p=0.573).
CONCLUSIONS
The expressions of the NF-κB were not associated with the clinical properties of clear cell RCC such as age, nuclear grade, TNM stage, and recurrence free survival.

Keyword

NF-κB; Renal cell carcinoma; Prognosis; Immunohistochemistry

MeSH Terms

Carcinoma, Renal Cell*
Humans
Immunohistochemistry
Prognosis
Recurrence
Transcription Factors
Transcription Factors