Korean J Urol Oncol.
2016 Aug;14(2):47-53. 10.22465/kjuo.2016.14.2.47.
Chemotherapy in Advanced Urothelial Carcinoma
- Affiliations
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- 1Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea. doctork@knu.ac.kr
- KMID: 2361563
- DOI: http://doi.org/10.22465/kjuo.2016.14.2.47
Abstract
- Despite recent advances in the management of a wide variety of solid tumors, the outcomes for patients with advanced urothelial carcinoma remain relatively poor. Cisplatin-based combination chemotherapy remains the standard of care for first-line systemic treatment of advanced urothelial carcinoma and for more than 10 years there have been no other Korean health insurance system-approved treatment options available for these patients. In this review article, we summarize the current state of chemotherapeutic agents, used either alone or in combination with other chemotherapy in advanced urothelial carcinoma. Our discussion focuses on the new agents for the cisplatin ineligible patients, including carboplatin, gemcitabine, paclitaxel, docetaxel and pemetrexed. Moreover, we addressed that neoadjuvant chemotherapy was supported in the patients planning radical cystectomy as an optimal treatment option by qualified studies.
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