Tissue Eng Regen Med.  2016 Dec;13(6):622-635. 10.1007/s13770-016-0145-4.

Advances in Three-Dimensional Bioprinting for Hard Tissue Engineering

Affiliations
  • 1Department of Biomedical Engineering, Pukyong National University, Busan, Korea.
  • 2Department of Molecular Science & Technology, Ajou University, Suwon, Korea. dr.bhmin@gmail.com
  • 3Cell Therapy Center, Ajou University Medical Center, Suwon, Korea.
  • 4Department of Orthopedic Surgery, School of Medicine, Ajou University, Suwon, Korea.

Abstract

The need for organ and tissue regeneration in patients continues to increase because of a scarcity of donors, as well as biocompatibility issues in transplant immune rejection. To address this, scientists have investigated artificial tissues as an alternative to transplantation. Three-dimensional (3D) bioprinting technology is an additive manufacturing method that can be used for the fabrication of 3D functional tissues or organs. This technology promises to replicate the complex architecture of structures in natural tissue. To date, 3D bioprinting strategies have confirmed their potential practice in regenerative medicine to fabricate the transplantable hard tissues, including cartilage and bone. However, 3D bioprinting approaches still have unsolved challenges to realize 3D hard tissues. In this manuscript, the current technical development, challenges, and future prospects of 3D bioprinting for engineering hard tissues are reviewed.

Keyword

Three-dimensional bioprinting; Hard tissue engineering; Cartilage; Bone; Tissue regeneration

MeSH Terms

Bioprinting*
Cartilage
Humans
Methods
Regeneration
Regenerative Medicine
Tissue Donors
Tissue Engineering*
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