Ann Dermatol.  1996 Apr;8(2):110-113. 10.5021/ad.1996.8.2.110.

Esptein-Barr Virus Associated Cutaneous Angiocetric Immunoproliferative Lesion Showing Histologic Features of Classical Lymphomatoid Granulomatosis

• Chi DH
• Huh JR
• Sung KJ
• Koh JK

• KMID: 2360540
• DOI: http://doi.org/10.5021/ad.1996.8.2.110

Abstract

We describe a patient with cutaneous angiocentric immunoproliferative lesion (AIL) associated with the Epstein-Barr virus (EBV). An organ system survey revealed no evidence of internal involvement. A skin biopsy specimen .showed infiltrating cells involving mainly deeper dermis and subcutaneous tissue. An examination of the reticular dermis revealed polymorphous angiocentric and angioinvasive infiltrate containing some atypical lymphocytes and histiocytes. EBV encoded RNA (EBER) was demonstrated in lesional skin by the in situ hybridization technique. On the basis of these findings, we conclude that our case may represent a form of AIL associated with EBV showing histologic features of classical lymphomatoid granulomatosis.

Keyword

Angiocentric immunoproliferative lesion; Epstein-Barr virus

MeSH Terms

Biopsy
Dermis
Herpesvirus 4, Human
Histiocytes
Humans
In Situ Hybridization
Lymphocytes
Lymphomatoid Granulomatosis*
RNA
Skin
Subcutaneous Tissue
RNA