Korean J Parasitol.  2015 Dec;53(6):755-757. 10.3347/kjp.2015.53.6.755.

Chronic Toxoplasmosis Modulates the Induction of Contact Hypersensitivity by TNCB in Mouse Model

• Yang Z
• Ahn HJ
• Nam HW

• KMID: 2360159
• DOI: http://doi.org/10.3347/kjp.2015.53.6.755

Abstract

Mouse models of chronic toxoplasmosis and atopic dermatitis (AD) were combined to clarify the effect of opportunistic Toxoplasma gondii infection on the development of AD. AD was induced as a chronic contact hypersensitivity (CHS) with repeated challenge of 2,4,6-trinitro-1-chlorobenzene (TNCB) on the dorsal skin of mice. TNCB induced skin thickness increases in both normal and toxoplasmic mice. The changing patterns were different from the sigmoidal which saturated at 20 days in normal mice to the convex saturated at 12 days in toxoplasmic mice with the crossing at 18 days. Compared to normal mice, toxoplasmic mice presented CHS more severely in earlier times and then moderately in later times. These data suggest that host immune modification by T. gondii infection enhances CHS in early times of atopic stimulation but soothes the reaction of CHS in later times in mouse model.

Keyword

Toxoplasma gondii; toxoplasmosis; contact hypersensitivity; atopic dermatitis; animal model

MeSH Terms

Animals
Dermatitis, Contact/*immunology/parasitology
Disease Models, Animal
Female
Humans
Mice
Mice, Inbred BALB C
Picryl Chloride/adverse effects
Skin/immunology/parasitology
Toxoplasmosis/*immunology/parasitology
Picryl Chloride