J Korean Radiol Soc.  1987 Feb;23(1):1-16. 10.3348/jkrs.1987.23.1.1.

An experimental study on microcholangiographic manifestation in extrahepatic bile duct obstruction

• Lee Y
• Kang HS
• Park JH
• Kim CW

• KMID: 2359648
• DOI: http://doi.org/10.3348/jkrs.1987.23.1.1

Abstract

Microcholangiography using microbarium was done for radiological observation of the morphology of intrahepaticmicrobiliary system and its change after extrahepatic bile duct obstruction. Regurgitation of microbarium into the systemic circulation was also observed. Extrahepatic bile ducts of 40 rabbits were ligated and microcholangiography was done just after ligation, after 1 day, 3 days and 5 days. In jection pressure of microbarium was 58cm H2O in 20 rabbits and 93cm H2O in another 20 rabbits. Histologic findings of the liver was compared with microcholangiographic findings. The results were as follows: 1. In microcholangiography, interlobular bile ducts and ductules were well noted, but bile canaliculi were not visible. 2. After extrahepaticbile duct ligation, ductules and small interlobular bile ducts were tortuously dilated and proliferated. These findings progressed according as the time after extrahepatic bile duct ligation especially between 1 and 2 days. 3. Micorbarium was regurgitated into hepatic sinusoids from a portal tract due to rupture of interlobular bileducts or ductules, and this was observed only in limited portions of sample tissue sections, but could be found inmost of 40 rabbits. From the above results, the morphology of intrahepatic microbiliary system and its change after extrahepatic bile duct obstruction could be radiologically observed with microcholangiography, so thistechnique could be used for an experimental study about the bilary system.

MeSH Terms

Bile Canaliculi
Bile Ducts
Bile Ducts, Extrahepatic*
Ligation
Liver
Rabbits
Rupture