J Korean Radiol Soc.  1990 Aug;26(4):640-644. 10.3348/jkrs.1990.26.4.640.

Intra-arterial infusion of prostaglandin E1 in Buerger's disease: report of 3 cases

• Kim YM
• Park JH
• Kim SJ

• KMID: 2359474
• DOI: http://doi.org/10.3348/jkrs.1990.26.4.640

Abstract

In Buerger's disease, arterial occlusion is so peripheral that reopening procedure such as recontruct ivevascular surgery, percutaneous trasluminal angioplasty and local fibrinolysis are not feasible, and majoramputation is the only alternative. Prostaglandin E1, a potent vasodilator and inhibitor of platelet aggregation, has been used to treat the patients with severe arterial occlusive disease. In three cases of Buerger's disease,who were manifested by resting pain, non-healing ischemic ulcer, or impending gangrene and who were not candidatesfor direct arterial reconstructive procedure, we infused Prsotaglandin E1 intra-arterially at a fixed dosage toevaluate its effectiveness. We report our experience with the use of this drug in relieving the ischemic symptoms, healing the intractable ulcer, or avoiding the major amputation.

MeSH Terms

Alprostadil*
Amputation
Angioplasty
Arterial Occlusive Diseases
Fibrinolysis
Gangrene
Humans
Infusions, Intra-Arterial*
Platelet Aggregation
Thromboangiitis Obliterans*
Ulcer
Alprostadil