J Korean Radiol Soc.  1990 Apr;26(2):223-229. 10.3348/jkrs.1990.26.2.223.

Hematogeneous pulmonary metastasis: an experimental study by using VX-2 carcinoma in rabbit

• Im JG
• Chung EC
• Han MH
• Han MC
• Ham EK

• KMID: 2358936
• DOI: http://doi.org/10.3348/jkrs.1990.26.2.223

Abstract

To evaluate sequential radiological changes and detectability of various radiological modalities inhematogeneous pulmonary metastasis we performed an experimental study by using VX-2 carcinoma in rabbits. Hematogeneous pulmonary metastasis was induced by injecting suspension of VX-2 carcinoma through the vein of theear. Five rabbits in each group were sacrificed after 3, 7, 14, 21 and 30 days of injection. Sequential follow-up chest radiography in vivo state and soft tissue ragiography, high resolution CT, microradiography of the inflated and fixed lungs were done. Gross pathological and radiological evidence of pulmonary meatstasis were seen in allrabbits sacrificed after 21 days. Chest radiographic evidence of pulmonary metastasis began to appear after 14 days of injection and showed well defined nodules about 4mm in diameter. High resolution CT of the inflated andfixed lung showed metastatic nodules at 7th day of injection as tiny nodules about 1mm in diameter. Besides thenodules, HRCT and microradiography showed clearly peribronchovascular and perinodular lymphangitic tumor spread inall five rabbits sacificed after 30 days. In conclusion, even with a guinuine hemotogeneous pulmonary metastasis, lymphagitic metastasis is associated in late stage of the disease and HRCT provides early detection of thenodules.

MeSH Terms

Follow-Up Studies
Lung
Microradiography
Neoplasm Metastasis*
Rabbits
Radiography
Radiography, Thoracic
Thorax
Veins