Korean J Anesthesiol.  1978 Sep;11(3):203-208.

Clinical Observation of Thalamonal-N2O-O2 Anesthesia for Neurosurgical Patients

• Kim KS
• Chon SU

Abstract

We have studied 20 neurosurgical patients who had clear consciousness with Thalamonal- N2O-O2 anesthesia. Induction of anesthesia consisted of the intravenous injection of Thalamonal (one ml injection of Thalamonal at one to two minute intervals), and administration of N2O-O2 (4: 2 L/min) in a semiclosed circle absorber system, and maintaining anesthesia with intermittent injections of Thalamonal and N2O-O2 (2:1 L/min) inhalation. At the end of operation, we observed the change of respiratoty parameters after reversal of Thalamonal effect with nalorphine by Wright spirometer. The results were as follows; 1) Average induction dose of Thalamonal was l. 23 ml/10 kg, and average dose of Thalamonal for maintenance of anesthesia was 0. 125 ml/10 kg/30 min. (mean anesthetic time: 3 hours 29 minutes) 2) During induction, change of blood pressure was significant (P<0.05), and change of pulse rate was insignificant (P>0.05). 3) Woody chest (4 cases among 20) and hypotension (1 case among 20) were observed during induction. 4) After reversal of Thalamonal effect with nalorphine, changes of respiratory rate (P <0. 01) and minute volume (P <0. 05) were significant, but change of tidal volume was insignificant (P>0.05) 5) After discontinuation of N2O, seventeen cases among 20 recovered promptly, and the recovery was delayed in the remainder. Most delayed case recovered about 6 hours after the end of operation was due to overdose. Therefore Thalamonal is a suitable anesthetic agent for neurosurgical patients.

MeSH Terms

Anesthesia*
Blood Pressure
Consciousness
Heart Rate
Humans
Hypotension
Inhalation
Injections, Intravenous
Nalorphine
Respiratory Rate
Thorax
Tidal Volume
Nalorphine