J Liver Cancer.  2016 Sep;16(2):145-150. 10.17998/jlc.2016.16.2.145.

A Case of Surgical Resection in Hepatocellular Carcinoma with Pulmonary Metastasis

• Jung WJ
• Jang JY
• Park JS
• Lee HJ
• Cho YK
• Jeong SW
• Lee SH
• Kim SG
• Cha SW
• Kim YS
• Cho YD
• Kim HS
• Kim BS

• KMID: 2357346
• DOI: http://doi.org/10.17998/jlc.2016.16.2.145

Abstract

Hepatocellular carcinoma (HCC) is well known malignancy with poor prognosis, even after resection of the primary tumor. Sorafenib is the first-line treatment in advanced HCC, but the disease control rate of sorafenib is only 43%. Pulmonary metastasectomy in patients with pulmonary metastasis from HCC has been reported to increase long-term survival compared with systemic chemotherapy. Video-assisted thoracic surgery is considered a reliable approach to the diagnosis and treatment of pulmonary diseases with low complication rate. Pulmonary metastasectomy is not universally accepted because of frequent local recurrence, an uncontrollable primary tumor, and frequent multiple pulmonary metastases in HCC, but outcome of pulmonary metastasectomy and adjuvant sorafenib therapy has not been studied. We experienced a patient who had advanced HCC with pulmonary oligometastasis and received surgical resection of the metastatic pulmonary nodule and sorafenib chemotherapy. In advanced HCC with pulmonary oligometastasis, surgical resection of pulmonary metastasis and sorafenib chemotherapy should be considered.

Keyword

Hepatocellular carcinoma; Metastasis; Metastasectomy; Sorafenib

MeSH Terms

Carcinoma, Hepatocellular*
Diagnosis
Drug Therapy
Humans
Lung Diseases
Metastasectomy
Neoplasm Metastasis*
Prognosis
Recurrence
Thoracic Surgery, Video-Assisted