J Liver Cancer.  2016 Sep;16(2):123-128. 10.17998/jlc.2016.16.2.123.

A Case of Achieving Complete Remission with Stereotactic Body Radiation Therapy in Patients with Hepatocellular Carcinoma with Macrovascular Invasion after Repeated Transarerial Chemoembolization

• Hwang SY
• Lee SM
• Im JW
• Jeon KJ
• Ahn SB
• Ji EK
• Park JY
• Choi CW
• Yang GM

• KMID: 2357342
• DOI: http://doi.org/10.17998/jlc.2016.16.2.123

Abstract

Transarterial chemoembolization (TACE) is the worldwide procedure performed for patients with various stage hepatoceullar carcinoma (HCC), but is not yet considered as curative treatment because of relatively high local recurrence rate. Moreover, many clinicians frequently experience treatment failure (incomplete necrosis or stage progression etc.) after repeated TACE, but no clear guidelines have been recommended about salvage treatment modalities for this situation. Recently, studies for combination of radiation therapy and TACE for HCC with TACE refractoriness have been tried and reported better therapeutic efficacy. Based on above suggestions, we herein offer our experience of a patient with macrovascular invasion developed after repeated TACE that achieve complete remission by stereotactic body radiation therapy. Further study, maybe regarding a combination of locoregional and systemic therapy, is necessary on how to manage HCC patients with TACE refractoriness.

Keyword

Hepatocellular carcinoma; Transarterial chemoembolization (TACE) refractory; Stereotactic body radiation therapy

MeSH Terms

Carcinoma, Hepatocellular*
Humans
Necrosis
Recurrence
Salvage Therapy
Treatment Failure