Korean J Neurotrauma.  2016 Oct;12(2):167-170. 10.13004/kjnt.2016.12.2.167.

Neural Axis Metastasis from Metachronous Pulmonary Basaloid Carcinoma Developed after Chemotherapy & Radiation Therapy of Uterine Cervical Carcinoma

Affiliations
  • 1Department of Neurosurgery, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea. neuri71@schmc.ac.kr
  • 2Department of Pathology, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea.
  • 3Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea.

Abstract

Multiple primary or secondary malignancies after anticancer therapy were recently reported to be increasing in frequency. The authors describe a case of metachronous metastatic pulmonary basaloid carcinoma to the central nervous system that was discovered after chemotherapy and radiation therapy for cervical uterine carcinoma. Two different types of cancer developed within some interval. There's the possibility that a secondary pulmonary neoplasm developed after the chemotherapy and radiotherapy conducted as cervical cancer treatment.

Keyword

Metachronous metastasis; Second primary neoplasm; Intramedullary tumor

MeSH Terms

Central Nervous System
Drug Therapy*
Lung Neoplasms
Neoplasm Metastasis*
Neoplasms, Second Primary
Radiotherapy
Uterine Cervical Neoplasms

Figure

  • FIGURE 1 Gross findings of wedge-resected lung show a 2.8×2.7-cm, well-circumscribed, whitish, firm, lobulated mass with hemorrhage and necrosis. (B) Microscopic findings show a well-circumscribed, lobulated, solid tumor with peripheral palisading and edematous lung parenchyma (hematoxylin and eosin [H & E] stain, ×40). (C) The tumor shows small cuboidal-to-fusiform tumor cells with moderately hyperchromatic nuclei and nuclear pleomorphism as well as multifocal necrosis (H & E stain, ×100). (D) Immunohistochemistry (IHC) of cytokeratin 7 reveals diffuse positivity in tumor cells (cytokeratin 7, ×200). (E) Immunohistochemistry of P16 reveals diffuse positivity in tumor cells (P16, ×100). (F) IHC of CD99 reveals dot-like positivity in tumor cell cytoplasm (CD99, ×200).

  • FIGURE 2 Brain magnetic resonance imaging with contrast enhancement. Shows 6×4-cm rim enhanced mass with vasogenic edema in the right parieto-occipital lobe.

  • FIGURE 3 Lumbar spine magnetic resonance imaging with contrast enhancement. Well enhancing contour bulging mass in the conus medullaris of the spinal cord at the T12-L1 level.

  • FIGURE 4 Lumbar-spine magnetic resonance imaging with contrast enhancement, postoperative status. Near total removal of metastatic lesion of the spinal cord.


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