J Korean Med Sci.  2009 Jun;24(3):542-545. 10.3346/jkms.2009.24.3.542.

Pure Basaloid Squamous Cell Carcinoma of the Uterine Cervix: A Case Report

• Kwon YS
• Kim YM
• Choi GW
• Kim YT
• Nam JH

• KMID: 1779181
• DOI: http://doi.org/10.3346/jkms.2009.24.3.542

Abstract

Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare malignancy of the female genital tract with a poorer clinical outcome than squamous cell carcinoma of the uterine cervix. We report a case of pure basaloid squamous cell carcinoma of the uterine cervix. A 70-yr-old woman with vaginal bleeding was referred to our institute. A basaloid squamous cell carcinoma of the uterine cervix, of International Federation of Gynecology and Obstetrics (FIGO) stage Ib1, was diagnosed by a loop electrosurgical excision procedure cone biopsy. A radical hysterectomy was performed, along with bilateral salpingo-oophorectomy, pelvic lymph node dissection, and para-aortic lymph node sampling. Pathologic findings were consistent with a basaloid squamous cell carcinoma confined to the cervix without an extracervical tumor. No further treatment was administered and there was no clinical evidence of recurrence during the 12 months of follow-up. Follow-up for the patient is ongoing. Although basaloid squamous cell carcinoma of the uterine cervix is thought to behave aggressively, accumulation of data on these rare tumors is necessary to determine whether their behavior differs significantly from that of conventional cervical squamous cell carcinoma of similar clinical stage. These data would be useful for defining the best diagnosis and treatment for these rare tumors.

Keyword

Basaloid; Carcinoma, Squamous Cell; Cervix Uteri

MeSH Terms

Aged
Carcinoma, Squamous Cell/*diagnosis/pathology/surgery
Colonoscopy
Female
Humans
Hysterectomy
Magnetic Resonance Angiography
Uterine Cervical Neoplasms/*diagnosis/pathology/surgery

Figure

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  Fig. 1 MRI findings in this patient. (A) T2 weighted image (B) T2 weighted image using an endorectal coil. The white arrow indicates a 2.0×1.6 cm cervical mass, comparable with cervical cancer.

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  Fig. 2 Histopathologic findings. The tumor is mainly composed of immature basaloid squamous cells with scanty cytoplasm and peripheral palisading (arrow). Keratinization foci are seen in the center of the nests (arrowhead). Both tumor components show p63 immunopositivity (A: H&E, ×200; B: p63, ×200).

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