J Rheum Dis.  2016 Oct;23(5):304-310. 10.4078/jrd.2016.23.5.304.

Association between Sugar-Sweetened Beverage Consumption and the Risk of Gout: A Meta-Analysis

• Lee YH
• Song GG

• KMID: 2356485
• DOI: http://doi.org/10.4078/jrd.2016.23.5.304

Abstract

OBJECTIVE
The aim of this study was to analyze published data for an association between consumption of sugar sweetened beverages (SSBs) and the development of gout.
METHODS
We performed a meta-analysis to examine the highest and lowest categories of SSB consumption in relation to risk of gout.
RESULTS
Three studies including 2,606 gout patients among 134,008 participants were included. Meta-analysis revealed a significant association between SSB consumption and gout risk (relative risk [RR]=1.986, 95% confidence interval [CI]=1.447~2.725, p=2.2×10⁻⁵). Stratification by ethnicity showed a significant association between SSB consumption and gout risk in ethnic Europeans, but not in Polynesians (RR=2.110, 95% CI=1.470~ 2.725, p=5.1×10⁻⁵; RR=1.624, 95% CI=0.842~3.135, p=0.148, respectively). SSB consumption and gout risk were associated in original data and imputed data, for both men and women, regardless of data type and sex. The association between the highest SSB consumption group and gout was stronger than the association between the middle group and gout, indicating a dose-response gradient (RR=1.986, 95% CI=1.447~2.725, p<2.2×10⁻⁵ vs. RR=1.260, 95% CI=1.043~1.522, p<0.016).
CONCLUSION
This meta-analysis of 134,008 participants demonstrates that SSB consumption is associated with an elevated risk of gout development, particularly in the ethnic European population. Available evidence indicates a dose-response gradient of the relationship between SSB consumption and gout risk.

Keyword

Sugar-sweetened beverages; Gout; Risk

MeSH Terms

Beverages*
Female
Gout*
Humans
Male

Figure

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  Figure 1. Flow chart for the study selection.

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  Figure 2. Meta-analysis of the association between sugar sweetened beverages (SSBs) consumption and gout risk for the highest versus lowest groups of SSBs intake in the overall group (A) and each ethnic group (B). CI: confidence interval.

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  Figure 3. Funnel plot of studies that examined the association between sugar sweetened beverages consumption and gout risk (Egger's regression test p-value=0.845). SE: standard error.

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