J Rheum Dis.  2016 Oct;23(5):288-296. 10.4078/jrd.2016.23.5.288.

Platelet Indices Are Associated with Disease Activity Scores and the Severity of Sacroiliitis on Magnetic Resonance Imaging in Axial Spondyloarthritis Patients

• Kang KY
• Jung JY
• Ju JH
• Park SH
• Hong YS

• KMID: 2356483
• DOI: http://doi.org/10.4078/jrd.2016.23.5.288

Abstract

OBJECTIVE
To investigate the associations among platelet indices, disease activity scores, and inflammatory markers in axial spondyloarthritis, and to determine the relation between platelet indices and inflammation measured on magnetic resonance imaging (MRI).
METHODS
The study included 161 patients who fulfilled Assessment of Spondyloarthritis International Society criteria. Platelet indices such as mean platelet volume (MPV), plateletcrit (PCT), platelet large cell ratio (PLCR), and platelet distribution width (PDW) were measured. Ninety patients underwent sacroiliac (SI) MRI at baseline. Bone marrow edema (BME) and erosion on MRI were scored using the SPondyloArthritis Research Consortium of Canada (SPARCC) method. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Disease Activity Score (ASDAS) and spinal radiologic progression were also assessed. The associations among platelet indices and disease activity scores and inflammatory markers were evaluated.
RESULTS
Of the 161 patients, 130 (81%) were male. MPV, PLCR, and PDW were negatively associated with ASDAS and inflammatory marker expression, whereas PCT was positively associated with these parameters. MPV, PLCR, and PDW were negatively associated with BME and erosion scores on SI MRI. However, platelet indices were not associated with the BASDAI and BASFI. The mean erythrocyte sedimentation rate, C-reactive protein, and BME and erosion scores were significantly higher in patients with low MPV. Changes in MPV, PCT, and PDW at baseline and after one year were associated with changes in ASDAS and inflammatory marker expression.
CONCLUSION
Platelet indices are associated with ASDAS, inflammatory marker levels, and severity of BME and erosion measured on MRI.

Keyword

Platelet index; Bone marrow edema; Erosion; Axial spondyloarthritis; Magnetic resonance imaging

MeSH Terms

Baths
Blood Platelets*
Blood Sedimentation
Bone Marrow
C-Reactive Protein
Canada
Edema
Humans
Inflammation
Magnetic Resonance Imaging*
Male
Mean Platelet Volume
Methods
Sacroiliitis*
Spondylitis, Ankylosing
C-Reactive Protein

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