Cancer Res Treat.  2016 Oct;48(4):1420-1428. 10.4143/crt.2015.309.

Clinical Practices and Outcomes on Chemotherapy-Induced Nausea and Vomiting Management in South Korea: Comparison with Asia-Pacific Data of the Pan Australasian Chemotherapy Induced Emesis Burden of Illness Study

Affiliations
  • 1Department of Internal Medicine, Seoul St. Mary's Hospital, Cancer Research Institution, The Catholic University of Korea, Seoul, Korea.
  • 2Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
  • 3Department of Internal Medicine, Dong-A University Hospital, Busan, Korea.
  • 4Department of Internal Medicine, Severance Hospital, Yonsei University, Seoul, Korea.
  • 5Merck Sharp and Dohme, Subsidiary of Merck and Co., Inc., Seoul, Korea.
  • 6Department of Oncology/Hematology, Kyungpook National University Medical Center, Daegu, Korea. jkk21c@knu.ac.kr

Abstract

PURPOSE
This study reported patient outcomes of chemotherapy-induced nausea and vomiting (CINV) prophylaxis for highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC) regimens and evaluated its adherence to acute-phase CINV prophylaxis in the Korean population subset of the Pan Australasian Chemotherapy Induced Emesis burden of illness (PrACTICE) study.
MATERIALS AND METHODS
This subgroup analysis evaluated 158 Korean patients receiving HEC or MEC and compared the data (wherever possible) with that of 648 patients from the Asia-Pacific (AP) region. Study endpoints included evaluation of primary CINV prophylaxis and adherence to acute-phase CINV prophylaxis in cycle 1 (American Society of Clinical Oncology [ASCO] Quality Oncology Practice Initiative [QOPI]).
RESULTS
In South Korea and the AP, a 5-hydroxytryptamine-3 receptor antagonist (5HT₃-RA) prophylaxis for the acute phase was administered to 79/80 patients (98.8%) for HEC and 70/71 patients (98.6%) for MEC regimens (QOPI-1). Triple regimen (corticosteroid-5HT₃-RA-neurokinin 1-RA) was initiated in 46/80 patients (57.5%) for prophylaxis of acute CINV in cycle 1 of HEC (QOPI-3). Double regimen (corticosteroid-5HT₃-RA, with or within NK₁-RA) was initiated in 61/71 patients (83.1%) for control of acute CINV in cycle 1 of MEC a(QOPI-2).
CONCLUSION
Active management of CINV is necessary in cycle 1 of HEC in South Korea, despite higher rates than the AP region. Adherence to the international guidelines for CINV prophylaxis requires attention in the acute phase in cycle 1 of the HEC regimen.

Keyword

Nausea; Vomiting; Drug therapy; Antiemetics

MeSH Terms

Antiemetics
Cost of Illness*
Drug Therapy*
Humans
Korea*
Medical Oncology
Nausea*
Receptors, Serotonin, 5-HT3
Vomiting*
Antiemetics
Receptors, Serotonin, 5-HT3

Figure

  • Fig. 1. Distribution of enrolled patients in PrACTICE (CONSORT flow diagram). PrACTICE, Pan Australasian Chemotherapy Induced Emesis burden of illness.


Reference

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