Perinatology.  2016 Sep;27(3):178-180. 10.14734/PN.2016.27.3.178.

A Case of Ibuprofen Induced Transient Platelet Dysfunction in Preterm Infant

  • 1Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.


Patent ductus arteriosus (PDA) in preterm infant is a common cardiovascular disease that result in hemodynamic disturbance. Ibuprofen treatment is currently being used for PDA closure either intravenously or enterally, and it has been demonstrated that ibuprofen have the same efficacy as indomethacin treatment for PDA closure. We encountered a case of severe gastrointestinal bleeding occurred in the administration of oral ibuprofen for the treatment of PDA in preterm infant. It was diagnosed with a transient platelet dysfunction due to oral ibuprofen treatment by analyzing through the Platelet function analysis (PFA) test. We present this case to emphasize the importance of close follow-up of preterm infant during oral ibuprofen treatment even though good enteral feeding.


Patent ductus arteriosus; Ibuprofen; Gastrointestinal bleeding; Platelet function analysis; Transient platelet dysfuction
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