Clin Exp Otorhinolaryngol.  2016 Sep;9(3):278-281. 10.21053/ceo.2015.01333.

Concurrent Mucosal Melanoma and Angiofibroma of the Nose

• Hwang JH
• Ha JB
• Lee J
• Lee J

• KMID: 2353628
• DOI: http://doi.org/10.21053/ceo.2015.01333

Abstract

Malignant melanoma rarely develops in the paranasal sinuses, and generally has a poor prognosis. However, mucosal melanoma can masquerade both clinically and histopathologically as a benign lesion, rendering accurate early diagnosis difficult. On the other hand, angiofibroma, a benign tumor, is more easily diagnosed than a mucosal melanoma, because the former exhibits specific histopathological features. No cases of concurrent angiofibroma and mucosal melanoma have been reported to date. We describe such a case below.

Keyword

Melanoma; Angiofibroma; Nasal cavity

MeSH Terms

Angiofibroma*
Early Diagnosis
Hand
Melanoma*
Nasal Cavity
Nose*
Paranasal Sinuses
Prognosis

Figure

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  Fig. 1. Preoperative endoscopic fi ndings in the right nasal cavity. S, septum; IT, inferior turbinate; T, tumor.

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  Fig. 2. Computed tomography reveals dense soft tissue in the right maxillary sinus and right nasal cavity. (A) Axial, (B) coronal images.

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  Fig. 3. Paranasal sinus magnetic resonance imaging fi ndings. An enhanced right antral mass with a widened maxillary ostium is evident; it extends into the right nasal cavity axial T2-weighted (A), axial T1-weighted (B), and coronal gadolinium-enhanced T1-weighted (C) images.

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  Fig. 4. Angiography with tumor embolization. The tumor was supplied by nasal branch of right sphenopalatine artery. (A) Before embolization, (B) after embolization.

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  Fig. 5. (A) Mucosal melanoma with an angiofi broma. Mucosal hyperpigmentation in subepithelium showing admixture of thin walled blood vessels and fi brous stroma (H&E: a, ×40; b, ×100). (B) The angiofi broma lesion of the specimen. Nasal mucosa with fi broblastic stroma and thin walled blood vessels (H&E, ×40). (C) Mucosal melanoma with intracytoplasmic melanic pigment (H&E: a, ×100; b, ×400). (D) Tumor cells positive for Melan-A (×40).

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