Korean J Pediatr.
2016 Jun;59(6):271-275. 10.3345/kjp.2016.59.6.271.
Clinical importance of F-waves as a prognostic factor in Guillain-Barré syndrome in children
- Affiliations
-
- 1Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea. sysnow88@hanmail.net
- 2Department of Physical Medicine and Rehabilitation, Yeungnam University College of Medicine, Daegu, Korea.
- 3Department of Pediatrics, Kyungpook National University Children's Hospital, Kyungpook National University School of Medicine, Daegu, Korea.
- KMID: 2353157
- DOI: http://doi.org/10.3345/kjp.2016.59.6.271
Abstract
- PURPOSE
A limited number of studies have examined the link between F-wave abnormalities and clinical presentation in pediatric Guillain-Barré syndrome (GBS). Therefore, this study examined the importance of F-wave abnormalities as a prognostic factor in pediatric GBS patients.
METHODS
The records and electrodiagnostic studies (EDS) of 70 GBS patients were retrospectively evaluated, and divided into 2 groups according to the results of EDS. Group A (n=33) presented with F-wave abnormalities, and group B (n=26) exhibited normal findings. We compared laboratory reports, clinical features, response to treatment, and prognosis between the 2 groups.
RESULTS
Motor weakness was the most frequently observed symptom for either group. Clinically, the incidence of fever and upper respiratory symptoms differed between the 2 groups, while the prevalence of abnormal deep tendon reflex (DTR) was significantly higher in group A than B (P<0.05). Patients diagnosed with GBS had received intravenous immunoglobulin treatment: 94% in group A and 58% in group B. Furthermore, significantly greater numbers of patients in group A showed H-reflex abnormalities and poor prognosis compared with group B (P<0.05).
CONCLUSION
This study demonstrated that F-waves are a clinically important prognostic factor in GBS. F-wave abnormalities were associated with abnormal DTR and poor prognosis in patients. Limited studies have examined the link between F-wave abnormalities and clinical results; therefore, further randomized controlled studies are needed to confirm the clinical characteristics and efficacy of treatments.
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