Ann Clin Neurophysiol.  2017 Jul;19(2):148-150. 10.14253/acn.2017.19.2.148.

Guillain-Barré syndrome associated with hyper-IgE-emia

• Choi J
• Rho JH
• Kim BJ

• KMID: 2387238
• DOI: http://doi.org/10.14253/acn.2017.19.2.148

Abstract

Peripheral neuropathy associated with hyper-IgE-emia have been rarely reported. Here we present a 72-year-old man with acute motor axonal neuropathy who had relatively poor prognosis. The serum was weakly positive for IgG GQ1b and GT1a, and serum IgE was significantly elevated. He was transferred to a rehabilitation center with Medical Research Council grade 3 lower extremity weakness on admission day 65. We would suggest that hyper-IgE-emia may increase the magnitude and rate of neural damage in this case.

Keyword

Guillain-Barré syndrome; Hyper-IgE-emia; Hyper IgE syndrome

MeSH Terms

Aged
Axons
Guillain-Barre Syndrome*
Humans
Immunoglobulin E
Immunoglobulin G
Job Syndrome
Lower Extremity
Peripheral Nervous System Diseases
Prognosis
Rehabilitation Centers
Immunoglobulin E
Immunoglobulin G

Figure

• 

  Fig. 1. Data from nerve conduction studies. Motor nerve conduction studies revealed normal velocities but variable decreases in amplitude in the median (A), ulnar (B), and tibial (C) nerves. The compound muscle action potential amplitude in the median nerve had improved by week 9, while that in the tibial nerve had decreased.

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