Clin Exp Reprod Med.  2016 Sep;43(3):181-184. 10.5653/cerm.2016.43.3.181.

Live birth in a woman with recurrent implantation failure and adenomyosis following transfer of refrozen-warmed embryos

• Safari S
• Faramarzi
• Agha-Rahimi A
• Khalili MA

• KMID: 2352853
• DOI: http://doi.org/10.5653/cerm.2016.43.3.181

Abstract

The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified. After 3 and 6 months, 3 and 4 B-C warmed embryos were transferred to the uterus, respectively. However, implantation did not take place. Ten months later, four embryos were warmed, two grade B 8-cell embryos were transferred, and two embryos were re-vitrified. One year later, the two re-vitrified cleavage-stage embryos were warmed, which resulted in a successful live birth. This finding showed that following first warming, it is feasible to refreeze supernumerary warmed embryos for subsequent ET in patients with a history of RIF.

Keyword

Adenomyosis; Embryo; Live birth; Vitrification

MeSH Terms

Adenomyosis*
Adult
Embryo Transfer
Embryonic Structures*
Female
Fertilization in Vitro
Humans
Live Birth*
Ovarian Hyperstimulation Syndrome
Polycystic Ovary Syndrome
Sperm Injections, Intracytoplasmic
Uterus
Vitrification