Ann Dermatol.  2015 Jun;27(3):319-321. 10.5021/ad.2015.27.3.319.

Infundibulocystic Squamous Cell Carcinoma

• Kim SM
• Kim H
• Kim HS
• Cho SH
• Lee JD

• KMID: 2352505
• DOI: http://doi.org/10.5021/ad.2015.27.3.319

Abstract

Infundibulocystic squamous cell carcinoma was first reported in 2008 as a subset of squamous cell carcinoma arising from the infundibulum of the hair follicle and exhibiting infundibular differentiation. It has well-differentiated, less-differentiated, and infiltrative forms. It was thoroughly analyzed in a series of cases in 2011 by Misago et al. and has been redefined to include only the infiltrative form owing to its unique clinical and histological characteristics. Here, we report an interesting case of infundibulocystic squamous cell carcinoma in a 72-year-old man presenting with a mass on the left helix of the ear.

Keyword

Squamous cell carcinoma

MeSH Terms

Aged
Carcinoma, Squamous Cell*
Ear
Hair Follicle
Humans

Figure

• 

  Fig. 1 A solitary 2-cm, crusted, fleshcolored, and rubbery mass on the left helix.

• 

  Fig. 2 Histological findings of the excised mass. (A) Infiltrating infundibular canals and radiating cords with multiple cysts in the dermis (H&E, ×40). (B) Multiple cysts filled with laminated keratin in the dermis (H&E, ×40). (C) Neoplasm cords or nests composed of atypical keratinocytes with hyperchromatism, pleomorphism, dyskeratosis, and minimal mitosis (H&E, ×200).

Reference

1. Kossard S, Tan KB, Choy C. Keratoacanthoma and infundibulocystic squamous cell carcinoma. Am J Dermatopathol. 2008; 30:127–134.

2. Diaz-Cascajo C, Borghi S, Weyers W, Bastida-Inarrea J. Follicular squamous cell carcinoma of the skin: a poorly recognized neoplasm arising from the wall of hair follicles. J Cutan Pathol. 2004; 31:19–25.

3. Misago N, Inoue T, Toda S, Narisawa Y. Infundibular (follicular) and infundibulocystic squamous cell carcinoma: a clinicopathological and immunohistochemical study. Am J Dermatopathol. 2011; 33:687–694.

4. Weedon D. Tumors of the epidermis. In : Weedon D, Strutton G, Rubin AI, editors. Weedon's skin pathology. 3rd ed. Edinburgh, United Kingdom: Churchill Livingstone;2010. p. 668–708.

5. Fischer S, Breuninger H, Metzler G, Hoffmann J. Microcystic adnexal carcinoma: an often misdiagnosed, locally aggressive growing skin tumor. J Craniofac Surg. 2005; 16:53–58.

6. Calonje E, Brenn T, Lazar A. Tumors of the sweat glands. In : Calonje E, Brenn T, Lazar A, Mckee PH, editors. Mckee's pathology of the skin: with clinical correlations. 4th ed. Edinburgh, United Kingdom: Elsevier Saunders;2012. p. 1559–1563.

7. Klingman DE, Chen S. Infundibular squamous cell carcinoma: a new entity? Am J Dermatopathol. 2012; 34:676–677.

8. Misago N. Controversial concepts: infundibular squamous cell carcinoma and tricholemmal carcinoma. Am J Dermatopathol. 2013; 35:523–524.